- Email: firstname.lastname@example.org
- Location: University of Leeds
- Supervisor: Carmen Molina-París
- Project title: Whole body models of human T cell maintenance
Short description of my project
We are seeking to understand the dynamics of T cell populations. From a mathematical point of view, many biological processes are modelled using Markov chains, therefore the underlying hypothesis is that interevent times are exponentially distributed.
However, recent works showed that this assumption is not appropriate for such processes where cell proliferation plays a key role. Indeed, the history-dependence nature of the cell cycle breaks the Markov property.
Multi-stage representations for cell proliferation are able to overcome this problem using Erlang distributions.
In this scenario, my project consists of two main parts:
- use a more general family of distributions, called Phase Type distributions, to represent the cell cycle;
- generalise the idea of multi-stage representations for cell proliferation to a model which involves also cell death and is able to track the number of divisions that the cell has undergone.
In the video below, Giulia describes why she decided to this PhD and her research project, and also explains the network (the video was created at the Complementary Skills Workshop in Leeds):