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Léa Sta

University of Leeds
Carmen Molina-París
Project title
Signals determining naive T cell maintenance

Short description of my project:

The aim of this project is to acquire a better understanding of T cell behaviour and T cell population homeostasis. To do so, I use mathematical tools to study receptor/interleukin binding models, focusing especially on IL-2 and IL-7. In some of the models, I am particularly interested in studying the influence of the number of available gamma chains on the dose response since the gamma chain is used in many interleukin receptors that can compete for this receptor subunit. These models can be compared with real data.

I am also developing mathematical models of the competition for IL-7 between T cells and innate lymphoid cells in lymph nodes.